Search on: EXTRACELLULAR SIGNAL-REGULATED MAP KINASES 
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Descriptor English:   Extracellular Signal-Regulated MAP Kinases 
Descriptor Spanish:   Quinasas MAP Reguladas por Seņal Extracelular 
Descriptor Portuguese:   MAP Quinases Reguladas por Sinal Extracelular 
Synonyms English:   ERK MAP Kinases
Extracellular Signal-Regulated Kinases
MAP Kinases, Extracellular Signal-Regulated  
Tree Number:   D08.811.913.696.620.682.700.567.342
D08.811.913.696.620.682.700.646.750.249
D12.644.360.450.169
D12.776.476.450.169
Definition English:   A mitogen-activated protein kinase subfamily that is widely expressed and plays a role in regulation of MEIOSIS; MITOSIS; and post mitotic functions in differentiated cells. The extracellular signal regulated MAP kinases are regulated by a broad variety of CELL SURFACE RECEPTORS and can be activated by certain CARCINOGENS. 
Indexing Annotation English:   note specifics
History Note English:   2005; for EXTRACELLULAR SIGNAL-REGULATED KINASES use MITOGEN-ACTIVATED PROTEIN KINASES 1994-2004 
Allowable Qualifiers English:  
AD administration & dosage AE adverse effects
AN analysis AI antagonists & inhibitors
BI biosynthesis BL blood
CF cerebrospinal fluid CS chemical synthesis
CH chemistry CL classification
CT contraindications DF deficiency
DU diagnostic use DE drug effects
EC economics GE genetics
HI history IM immunology
IP isolation & purification ME metabolism
PK pharmacokinetics PD pharmacology
PH physiology PO poisoning
RE radiation effects SE secretion
ST standards SD supply & distribution
TU therapeutic use TO toxicity
UL ultrastructure UR urine
Record Number:   38727 
Unique Identifier:   D048049 

Occurrence in VHL:
 

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